Bipolar Disord. 1999 Sep;1(1):42-53. Topiramate as add-on treatment for patients with bipolar mania. Chengappa KN(1), Rathore D, Levine J, Atzert R, Solai L.
The study had a prospective open label, add-on design. Topiramate was introduced at a dose of 25 mg/day, and increased by 25 mg/day every.
TOPAMAX is indicated in adults for the prophylaxis of migraine headache. Adults: Titration for add-on therapy should begin at 25 to 50 mg as a single ( nightly).